UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.

doi:10.1182/blood.2019001044

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Article

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.

Blood - 18 Feb 2021

Sera Yasuyuki, Nakata Yuichiro, Ueda Takeshi, Yamasaki Norimasa, Koide Shuhei, Kobayashi Hiroshi, Ikeda Ken-Ichiro, Kobatake Kohei, Iwasaki Masayuki, Oda Hideaki, Wolff Linda, Kanai Akinori, Nagamachi Akiko, Inaba Toshiya, Sotomaru Yusuke, Ichinohe Tatsuo, Koizumi Miho, Miyakawa Yoshihiko, Honda Zen-Ichiro, Iwama Atsushi, Suda Toshio, Takubo Keiyo, Honda Hiroaki

Abstract excerpt

Epigenetic regulation is essential for the maintenance of the hematopoietic system, and its deregulation is implicated in hematopoietic disorders. In this study, UTX, a demethylase for lysine 27 on histone H3 (H3K27) and a component of COMPASS-like and SWI/SNF complexes, played an essential role in the hematopoietic system by globally regulating aging-associated genes. Utx-deficient (UtxΔ/Δ) mice exhibited...

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PMID: 33174606
DOI: 10.1182/blood.2019001044
PMCID: PMC7918186

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