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Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies

10 Aug 2019

Abstract excerpt

Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of red blood cells and decreased generation of immune cells. These changes result in anaemia, increased susceptibility for infections and higher prevalence of...

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PMID: 31405121
DOI: 10.3390/cells8080868

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