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A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy

17 Jan 2025

Abstract excerpt

To identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared. Human specimens consist of CD34+ cells from bone marrow, and mouse specimens of hematopoietic stem cells (HSCs; Lin- Kit+ Sca1+ CD150+)....

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PMID: 39859500
DOI: 10.3390/ijms26020787

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