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Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis

2 Jan 2025

Abstract excerpt

Ex vivo expansion of hematopoietic stem cells (HSC) requires the maintenance of a stemness state while cells are proliferating. This can be achieved via exposure to UM171 which leads to the degradation of chromatin modifiers and prevents the loss of key epigenetic marks. However, the chromatin landscape varies across populations within the hematopoietic system and the effect of UM171 on self-renewal and...

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PMID: 39747844
DOI: 10.1038/s41467-024-55225-7

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