Article

The pre-clinical evolution of haematological malignancies

2019-01-01

Abstract excerpt

Cancer-associated somatic mutations frequently drive clonal expansions in normal ageing tissues. However, the factors governing whether pre-cancerous cells transform into cancer are poorly understood, hindering identification of clones that are clinically significant rather than benign sequelae of ageing. The main aim of this dissertation has been to explore this process in the haematopoietic system, where leukaem...

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Literature Corpus work: c3196ba9-1d66-51e1-8eff-76f78fc82933
DOI: 10.17863/cam.65763

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