Article

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

2023-12-16

Abstract excerpt

The representation of driver mutations in preleukemic haematopoietic stem cells (pHSCs) provides a window into the somatic evolution that precedes Acute Myeloid Leukemia (AML). Here, we isolate pHSCs from the bone marrow of 16 patients diagnosed with AML and perform single-cell DNA sequencing on thousands of cells to reconstruct phylogenetic trees of the major driver clones in each patient. We develop a computatio...

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Literature Corpus work: b01df924-f454-54f5-b61a-89af0a08285c
DOI: 10.1101/2023.12.15.571872

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