Article

Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system

2022-07-14

Abstract excerpt

Microglia regulate multiple processes in the central nervous system, exhibiting a significant level of cellular plasticity which is facilitated by an equally dynamic transcriptional environment. While many gene networks that regulate microglial functions have been characterised, the influence of epigenetic regulators such as small non-coding microRNAs (miRNAs) is less well defined. We have sequenced the miRNAome a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95e7079a-f7bf-571d-8555-becc14fb1fbd
DOI: 10.1101/2022.07.12.499835

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous systemDOI 10.1101/2022.07.12.499835Read

The transcriptional landscape of human microglia reveals strong conservation of miRNAs and preservation of function across vertebrate speciesSemantic proximity Read

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencingSemantic proximity Read

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read

Regional and sub-regional microglial heterogeneity in the steady-state mouse brain and retinaSemantic proximity Read

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function.Semantic proximity Read

Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial PerspectiveSemantic proximity Read

Dynamics of microRNA expression during mouse prenatal developmentSemantic proximity Read

Myeloid masquerade: Microglial transcriptional signatures in retinal development and diseaseSemantic proximity Read

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.Semantic proximity Read

Single nucleus RNA-sequencing study revealed expansion of Gpnmb+ microglia in aged mouse spinal cordSemantic proximity Read

Dicer deficiency in microglia leads to accelerated demyelination and failed remyelinationSemantic proximity Read

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programsSemantic proximity Read