Article

Iteratively improving Hi-C experiments one step at a time

2018-03-22

Abstract excerpt

The 3D organization of eukaryotic chromosomes affects key processes such as gene expression, DNA replication, cell division, and response to DNA damage. The genome-wide chromosome conformation capture (Hi-C) approach can characterize the landscape of 3D genome organization by measuring interaction frequencies between all genomic regions. Hi-C protocol improvements and rapid advances in DNA sequencing power have ma...

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Literature Corpus work: 820d48f5-bf97-5b1e-a393-07943d66fe22
DOI: 10.1101/287201

Open publication

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