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Article

Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

Nature methods - 1 Jan 2016

Davies James O J, Telenius Jelena M, McGowan Simon J, Roberts Nigel A, Taylor Stephen, Higgs Douglas R, Hughes Jim R

Abstract excerpt

Methods for analyzing chromosome conformation in mammalian cells are either low resolution or low throughput and are technically challenging. In next-generation (NG) Capture-C, we have redesigned the Capture-C method to achieve unprecedented levels of sensitivity and reproducibility. NG Capture-C can be used to analyze many genetic loci and samples simultaneously. High-resolution data can be produced with as few...

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Share to Chromosomes, Human
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26595209
DOI: 10.1038/nmeth.3664
PMCID: PMC4724891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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