Article
A Standardized Protocol for Sample Preparation for Scanning Electron Microscopy (SEM) to Visualize Extrachromosomal DNA (ecDNA)
2023-08-24
Abstract excerpt
Extrachromosomal DNA (ecDNA) are large (∼kilo to megabase) acentric, atelomeric, circular DNAs that are established cytogenetic markers for malignancy, hard-to-treat tumors and drug resistance. Often referred to as double minute chromosomes, ecDNA have been studied since the 1960s, primarily through molecular biology techniques, such as cytogenetics and fluorescence microscopy. More recently, next generation seque...
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Identifiers and source
- Literature Corpus work
- 2ddd283e-bc25-5dda-b779-eaf85f71ee1c
- DOI
- 10.1101/2023.08.24.554665