HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures <i>in vitro</i>

Abstract excerpt

Disease-associated microglia (DAM), initially described in mouse models of neurodegenerative diseases, have been classified into two related states; starting from a TREM2-independent DAM1 state to a TREM2 dependent state termed DAM2, with each state being characterized by the expression of specific marker genes 1 . Recently, single-cell (sc)RNA-Seq studies have reported the existence of DAMs in humans 2–6 ; howe...

Topics

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• Chemokine CXCL12
• Chemotaxis
• Gene Knockout Techniques
• Microglia
• Phagocytosis
• Plaque, Amyloid
• Receptors, CXCR4
• Receptors, Immunologic

Identifiers and source

Literature Corpus work

81e502b5-f98a-53ff-8b9e-8d4e6c736556

DOI

10.1101/2024.10.11.617544