Article
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2021
Ellwanger Daniel C, Wang Shoutang, Brioschi Simone, Shao Zhifei, Green Lydia, Case Ryan, Yoo Daniel, Weishuhn Dawn, Rathanaswami Palaniswami, Bradley Jodi, Rao Sara, Cha Diana, Luan Peng, Sambashivan Shilpa, Gilfillan Susan, Hasson Samuel A, Foltz Ian N, van Lookeren Campagne Menno, Colonna Marco
Abstract excerpt
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer's disease (AD) risk is associated with the TREM2R47H variant, which impairs ligand binding and consequently microglia responses to Aβ pathology. Here, we show that TREM2 engagement by the mAb hT2AB as surrogate ligand activates...
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