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Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice

2024-11-15

Abstract excerpt

<h4>Background</h4> A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation, namely the “Warburg effect”, represents a hallmark of cancer cells. Hexokinases (HK) catalyze the first step of glycolysis, thereby regulating its rate. Dysregulated HKDC1 (HK domain containing 1) expression has been associated with various cancer types and blocking HKDC1 prevents disease progression for hepatic car...

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Literature Corpus work
81cc308d-381e-5bef-8dc3-414525b60600
DOI
10.1101/2024.11.15.623798
Open publication

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