Article

Tight Junction-high and CDH17-positive cell population is the Source of Colorectal Cancer Liver Metastases

2025-07-09

Abstract excerpt

<title>Abstract</title> <p>The IKKα kinase is increasingly emerging as a critical regulator of oncogenic and therapy-resistance elements including ATM/DDR, BRD4, and JAK/STAT, operating independently of canonical NF-κB signaling. Here, we reveal an unexpected metastasis suppressor role for IKKα in colorectal cancer (CRC). Specifically, genetic or pharmacological inhibition of IKKα in patient-derived organoids (PD...

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Literature Corpus work: d7ec3e60-e71b-53f7-b21b-e746a762507a
DOI: 10.21203/rs.3.rs-6998644/v1

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