Article
The oncogenic role of U2AF2/HKDC1 cascade in colorectal cancer by promoting cancer cell glycolysis and malignant phenotypes.
Mutation research - 1 Jan 2026
Feng Wenjuan, Wu Mingfeng, Zou Hanyang, Chen Yanpu
Abstract excerpt
BACKGROUND: Dysregulation of hexokinase domain component 1 (HKDC1), a central regulator of glucose metabolism, plays a pathogenic role in colorectal cancer (CRC). The current research investigated the RNA-binding protein (RBP)-mediated mechanism in driving HKDC1 dysregulation in CRC. METHODS: Expression of mRNAs was detected by quantitative PCR, and protein expression analysis was performed by immunoblot and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.