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ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer

15 Jun 2025

Abstract excerpt

Colorectal cancer (CRC) remains a significant health challenge globally, demanding a comprehensive understanding of its molecular underpinnings for effective management. In this study, we investigated the role of Aldolase C (ALDOC), a glycolytic enzyme, in CRC pathogenesis. Transcriptomic analysis of CRC tissues from The Cancer Genome Atlas (TCGA) revealed a substantial upregulation of ALDOC, correlating with...

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PMID: 40518543
DOI: 10.1186/s10020-025-01252-z

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