Article

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

2024-04-06

Abstract excerpt

<h4>Background</h4> Inflammation is characterized by a metabolic switch promoting glycolysis and lactate production. Hexokinases (HK) catalyze the first reaction of glycolysis and inhibition of epithelial HK2 protected from colitis in mice. HK2 expression has been described as elevated in patients with intestinal inflammation, however there is conflicting data from few cohorts especially with severely inflamed in...

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Literature Corpus work: 320ce87b-aaeb-5063-af12-c956d675d861
DOI: 10.1101/2024.04.04.588060

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