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Article

Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2021

Shneider Benjamin L, Cortes-Santiago Nahir, Schady Deborah A, Krishnamoorthy Swapna, Thevananther Sundararajah, Rajapakshe Kimal, Perera Dimuthu, Huang Shixia, Coarfa Cristian

Abstract excerpt

Activation of mitogen-activated protein kinases (MAPKs) is a key factor in the pathogenesis of cancer, although the specific role of mitogen-activated protein kinase kinase (MEK1) is not well understood. Villin promoter-driven Cre expression was used to excise a floxed stop cassette from a phosphomimetically constitutively activated MEK1 (caMEK1) expression construct in the intestine of C57BL/6 mice. Zygosity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33470189
DOI: 10.1152/ajpgi.00065.2020
PMCID: PMC8202241

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