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The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression

28 Jul 2022

Abstract excerpt

Liver cancer (LC) is the fourth leading cause of death from cancer malignancies. Recently, a putative fifth hexokinase, hexokinase domain containing 1 (HKDC1), was shown to have significant overexpression in LC compared to healthy liver tissue. Using a combination of in vitro and in vivo tools, we examined the role of HKDC1 in LC development and progression. Importantly, HKDC1 ablation stops LC development and...

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PMID: 35902556
DOI: 10.1038/s41419-022-04999-z

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