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Article

Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer.

Biochemical genetics - 1 Aug 2023

Atalay Esra Bulut, Senturk Serif, Kayali Hulya Ayar

Abstract excerpt

The isocitrate dehydrogenase (IDH), which participates in the TCA cycle, is an important key enzyme in regulating cell metabolism. The effect of the metabolic IDH enzyme on cancer pathogenesis has recently been shown in different types of cancer. However, the role of wild-type (wt) IDH1 in the development of colon cancer is still unknown. Our study investigated the role of the IDH1 enzyme in key hallmarks of...

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Identifiers

PMID: 36633771
DOI: 10.1007/s10528-022-10325-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer.PMID 36633771Read ↗

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