Article

Context-specific eQTL dynamics uncover genetic pleiotropy and chromatin-mediated target gene switching in schizophrenia

2025-05-06

Abstract excerpt

<title>Abstract</title> <p>Schizophrenia is a highly heritable psychiatric disorder, but functional mechanisms linking genetic risk to pathogenesis remain poorly understood. Most schizophrenia-associated variants reside in non-coding regions, highlighting the need to investigate their regulatory roles. This study employs context-specific expression quantitative trait loci (eQTL) analysis using the BrainSeq Phase...

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Literature Corpus work: 81c8c5fc-80c8-50c9-9c76-3f484344453c
DOI: 10.21203/rs.3.rs-6582362/v1

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