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Article

Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia.

Molecular psychiatry - 1 Dec 2022

Alver Maris, Lykoskoufis Nikolaos, Ramisch Anna, Dermitzakis Emmanouil T, Ongen Halit

Abstract excerpt

Schizophrenia is a polygenic psychiatric disorder with limited understanding about the mechanistic changes in gene expression regulation. To elucidate on this, we integrate interindividual variability of regulatory activity (ChIP-sequencing for H3K27ac histone mark) with gene expression and genotype data captured from the prefrontal cortex of 272 cases and controls. By measuring interindividual correlation among...

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Identifiers

PMID: 36114277
DOI: 10.1038/s41380-022-01768-4
PMCID: PMC9763101

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