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Article

Context-specific expression quantitative trait loci dynamics uncover genetic pleiotropy in schizophrenia.

Neurobiology of disease - 1 Jan 2026

Ye Linyan, Shen Zongrui, Yang Qi, Wu Xiaohui, Ye Junping, Li Zhongwei, Xiong Fu, Che Siyao, Zhao Cunyou, Wang Zhongju

Abstract excerpt

Schizophrenia (SCZ) is a highly heritable psychiatric disorder, yet the mechanisms linking genetic risk to pathogenesis remain unclear. This study employs context-specific expression quantitative trait loci (eQTL) analysis using the BrainSeq Phase 1 dataset to dissect schizophrenia-associated regulatory dynamics. We identified widespread loss and gain of regulatory associations in schizophrenia group versus...

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PMID: 41448503
DOI: 10.1016/j.nbd.2025.107236

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