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Article

Convergence of the dysregulated regulome in schizophrenia with polygenic risk and evolutionarily constrained enhancers.

Molecular psychiatry - 1 Mar 2024

Dong Pengfei, Voloudakis Georgios, Fullard John F, Hoffman Gabriel E, Roussos Panos

Abstract excerpt

Enhancers play an essential role in the etiology of schizophrenia; however, the dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains understudied. To address this gap in our knowledge, we assessed enhancer and gene expression in 1,382 brain samples comprising cases with schizophrenia and unaffected controls. Dysregulation of enhancer expression was concordant with changes in...

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Identifiers

PMID: 38145985
DOI: 10.1038/s41380-023-02370-y
PMCID: PMC11153027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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