Article
Use of the epigenetic toolbox to contextualize common variants associated with schizophrenia risk .
Dialogues in clinical neuroscience - 1 Dec 2019
Rajarajan Prashanth, Akbarian Schahram
Abstract excerpt
Schizophrenia is a debilitating psychiatric disorder with a complex genetic architecture and limited understanding of its neuropathology, reflected by the lack of diagnostic measures and effective pharmacological treatments. Geneticists have recently identified more than 145 risk loci comprising hundreds of common variants of small effect sizes, most of which lie in noncoding genomic regions. This review will...
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