Article

Schizophrenia Risk Alleles Often Affect the Expression of Many Genes and Each Gene May Have a Different Effect on The Risk; A Mediation Analysis

2020-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Variants identified by genome-wide association studies (GWAS) are often expression quantitative trait loci (eQTLs), suggesting they are proxies or are themselves regulatory. Across many datasets analyses show that variants often affect multiple genes. Lacking data on many tissue types, developmental time points and homogeneous cell types, the extent of this one-to-many relationship is underestim...

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Literature Corpus work: 47b680c4-0524-54e3-a963-d5265aa95062
DOI: 10.1101/2020.01.27.904680

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