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Article

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.

Nature neuroscience - 1 Aug 2018

Jaffe Andrew E, Straub Richard E, Shin Joo Heon, Tao Ran, Gao Yuan, Collado-Torres Leonardo, Kam-Thong Tony, Xi Hualin S, Quan Jie, Chen Qiang, Colantuoni Carlo, Ulrich William S, Maher Brady J, Deep-Soboslay Amy, Cross Alan J, Brandon Nicholas J, Leek Jeffrey T, Hyde Thomas M, Kleinman Joel E, Weinberger Daniel R

Abstract excerpt

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using developmental, genetic and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of shifting isoform usage across...

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Identifiers

PMID: 30050107
DOI: 10.1038/s41593-018-0197-y
PMCID: PMC6438700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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