An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.

doi:10.1186/s13059-016-1041-x

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An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.

Genome biology - 30 Aug 2016

Hannon Eilis, Dempster Emma, Viana Joana, Burrage Joe, Smith Adam R, Macdonald Ruby, St Clair David, Mustard Colette, Breen Gerome, Therman Sebastian, Kaprio Jaakko, Toulopoulou Timothea, Hulshoff Pol Hilleke E, Bohlken Marc M, Kahn Rene S, Nenadic Igor, Hultman Christina M, Murray Robin M, Collier David A, Bass Nick, Gurling Hugh, McQuillin Andrew, Schalkwyk Leonard, Mill Jonathan

Abstract excerpt

BACKGROUND: Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by episodic psychosis and altered cognitive function. Despite success in identifying genetic variants associated with schizophrenia, there remains uncertainty about the causal genes involved in disease pathogenesis and how their function is regulated. RESULTS: We performed a multi-stage epigenome-wide association study,...

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PMID: 27572077
DOI: 10.1186/s13059-016-1041-x
PMCID: PMC5004279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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