In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy.

doi:10.1016/j.ccell.2024.10.009

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Article

In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy.

Cancer cell - 11 Nov 2024

Bowman Robert L, Dunbar Andrew J, Mishra Tanmay, Xiao Wenbin, Waarts Michael R, Maestre Inés Fernández, Eisman Shira E, Cai Louise, Mowla Shoron, Shah Nisargbhai, Youn Angela, Bennett Laura, Fontenard Suean, Gounder Shreeya, Gandhi Anushka, Bowman Michael, O'Connor Kavi, Zaroogian Zachary, Sánchez-Vela Pablo, Martinez Benitez Anthony R, Werewski Matthew, Park Young, Csete Isabelle S, Krishnan Aishwarya, Lee Darren, Boorady Nayla, Potts Chad R, Jenkins Matthew T, Cai Sheng F, Carroll Martin P, Meyer Sara E, Miles Linde A, Ferrell P Brent, Trowbridge Jennifer J, Levine Ross L

Abstract excerpt

Cancer evolution is a multifaceted process leading to dysregulation of cellular expansion and differentiation through somatic mutations and epigenetic dysfunction. Clonal expansion and evolution is driven by cell-intrinsic and -extrinsic selective pressures, which can be captured with increasing resolution by single-cell and bulk DNA sequencing. Despite the extensive genomic alterations revealed in profiling...

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Identifiers

PMID: 39532065
DOI: 10.1016/j.ccell.2024.10.009
PMCID: PMC11561369

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