Article
Modeling and targeting of erythroleukemia by hematopoietic genome editing.
Blood - 25 Mar 2021
Iacobucci Ilaria, Qu Chunxu, Varotto Elena, Janke Laura J, Yang Xu, Seth Aman, Shelat Anang, Friske Jake D, Fukano Reiji, Yu Jiyang, Freeman Burgess B, Kennedy James A, Sperling Adam S, Zheng Rena, Wang Yingzhe, Jogiraju Harini, Dickerson Kirsten M, Payne-Turner Debbie, Morris Sarah M, Hollis Emily S, Ghosn Nina, Haggard Georgia E, Lindsley R Coleman, Ebert Benjamin L, Mullighan Charles G
Abstract excerpt
Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant assays, we developed preclinical models of AEL and non-erythroid acute leukemia and describe the central role of mutational cooperativity in determining leukemia lineage....
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