Article

Early drivers of clonal hematopoiesis shape the evolutionary trajectories of <i>de novo</i> acute myeloid leukemia

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Mutations commonly found in AML such as DNMT3A , TET2 and ASXL1 can be found in the peripheral blood of otherwise healthy adults – a phenomenon referred to as clonal hematopoiesis (CH). These mutations are thought to represent the earliest genetic events in the evolution of AML. Genomic studies on samples acquired at diagnosis, remission, and at relapse have demonstrated significant stability...

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Literature Corpus work: 672afb46-28cb-5013-99a8-918599f29495
DOI: 10.1101/2024.08.31.24312756

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