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Article

Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.

Leukemia - 1 Jul 2019

Loberg Matthew A, Bell Rebecca K, Goodwin Leslie O, Eudy Elizabeth, Miles Linde A, SanMiguel Jennifer M, Young Kira, Bergstrom David E, Levine Ross L, Schneider Rebekka K, Trowbridge Jennifer J

Abstract excerpt

Clonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a lack of in vivo models that orthogonally activate mutant alleles. Here, we develop independently regulatable mutations in DNA methyltransferase 3A (Dnmt3a) and nucleophosmin 1 (Npm1), observed in human CH...

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Share to Clonal Evolution
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 30692594
DOI: 10.1038/s41375-018-0368-6
PMCID: PMC6609470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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