Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.

Cell stem cell - 3 Jun 2021

Wang Tiansu, Pine Allison R, Kotini Andriana G, Yuan Han, Zamparo Lee, Starczynowski Daniel T, Leslie Christina, Papapetrou Eirini P

Abstract excerpt

Human cancers arise through the sequential acquisition of somatic mutations that create successive clonal populations. Human cancer evolution models could help illuminate this process and inform therapeutic intervention at an early disease stage, but their creation has faced significant challenges. Here, we combined induced pluripotent stem cell (iPSC) and CRISPR-Cas9 technologies to develop a model of the clonal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clustered Regularly Interspaced Short Palindromic Repeats

Share to CRISPR and Genetic Engineering

Share to Gene Editing

Share to Induced Pluripotent Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 33571445
DOI: 10.1016/j.stem.2021.01.011
PMCID: PMC8178190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.PMID 33571445Read ↗

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemiaSemantic proximity Read ↗

Studying clonal evolution of myeloid malignancies using induced pluripotent stem cellsSemantic proximity Read ↗

Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.Semantic proximity Read ↗

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.Semantic proximity Read ↗

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia.Semantic proximity Read ↗

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid LeukemiaSemantic proximity Read ↗

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.Semantic proximity Read ↗

A guide to epigenetics in leukaemia stem cells.Semantic proximity Read ↗

Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemiaSemantic proximity Read ↗

The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia DevelopmentSemantic proximity Read ↗

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read ↗

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML DifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.