Article

APOBEC3 mutagenesis drives therapy resistance in breast cancer

2024-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Acquired genetic alterations commonly drive resistance to endocrine and targeted therapies in metastatic breast cancer 1–7 , however the underlying processes engendering these diverse alterations are largely uncharacterized. To identify the mutational processes operant in breast cancer and their impact on clinical outcomes, we utilized a well-annotated cohort of 3,880 patient samples with paire...

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Literature Corpus work: 81c785bb-042c-59d8-af67-b743f0437b75
DOI: 10.1101/2024.04.29.591453

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