Article

APOBEC3B mRNA Expression in Breast Cancer Correlates with Genomic Mutational Signatures

2026-08-24

Abstract excerpt

Despite advances in screening and treatment, breast cancer remains a leading cause of cancer-related mortality. APOBEC enzymes, particularly APOBEC3B (A3B), are upregulated in many cancers, contributing to a characteristic C-to-T mutational signature found in 30-50% of breast cancers. However, the relationship between A3B mutational signatures and A3B expression across subtypes, and the resulting potential biologi...

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Literature Corpus work: b0e4d836-74fe-521d-913d-04461b8fd538
DOI: 10.64898/2026.08.20.745899

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