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Genomic Divergence Between Matched Primary and Metastatic Tumors Across Cancer Types: A Pan-Cancer Analysis of 5,692 Samples

2025-08-26

Abstract excerpt

<h4>Introduction</h4> Metastasis represents the leading cause of cancer-related mortality and is characterized by complex biological processes such as genomic instability, immune evasion, and therapy resistance. While metastatic tumors often retain the truncal drivers of their primary counterparts, the extent and nature of additional somatic alterations acquired during progression remain incompletely defined acro...

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Literature Corpus work
4c9dcf8e-4a4c-5867-bafd-95ba0e422ce7
DOI
10.1101/2025.08.22.25334215
Open publication

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Genomic Divergence Between Matched Primary and Metastatic Tumors Across Cancer Types: A Pan-Cancer Analysis of 5,692 SamplesDOI 10.1101/2025.08.22.25334215
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