APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.

Abstract excerpt

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine deaminases involved in innate and adaptive immunity. However, some APOBEC family members can also deaminate host genomes to generate oncogenic mutations. The resulting mutations, primarily signatures 2 and 13, occur in many tumor types and are among the most common mutational signatures in cancer. This review summarizes the...

Topics

• Humans
• Clinical Relevance
• Neoplasms
• Mutagenesis
• Mutation
• Peptides
• Cytidine Deaminase
• Tumor Microenvironment
• APOBEC Deaminases