Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy⋆.

doi:10.1016/j.annonc.2020.12.016

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Article

Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy⋆.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2021

Denkert C, Untch M, Benz S, Schneeweiss A, Weber K E, Schmatloch S, Jackisch C, Sinn H P, Golovato J, Karn T, Marmé F, Link T, Budczies J, Nekljudova V, Schmitt W D, Stickeler E, Müller V, Jank P, Parulkar R, Heinmöller E, Sanborn J Z, Schem C, Sinn B V, Soon-Shiong P, van Mackelenbergh M, Fasching P A, Rabizadeh S, Loibl S

Abstract excerpt

BACKGROUND: Different endogenous and exogenous mutational processes act over the evolutionary history of a malignant tumor, driven by abnormal DNA editing, mutagens or age-related DNA alterations, among others, to generate the specific mutational landscape of each individual tumor. The signatures of these mutational processes can be identified in large genomic datasets. We investigated the hypothesis that genomic...

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PMID: 33418062
DOI: 10.1016/j.annonc.2020.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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