The Influence of Cancer Molecular Subtypes and Treatment on the Mutation Spectrum in Metastatic Breast Cancers.

doi:10.1158/0008-5472.CAN-19-3260

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Article

The Influence of Cancer Molecular Subtypes and Treatment on the Mutation Spectrum in Metastatic Breast Cancers.

Cancer research - 1 Aug 2020

Verret Benjamin, Sourisseau Tony, Stefanovska Bojana, Mosele Fernanda, Tran-Dien Alicia, André Fabrice

Abstract excerpt

Next-generation sequencing has sparked the exploration of cancer genomes, with the aim of discovering the genetic etiology of the disease and proposing rationally designed therapeutic interventions. Driver gene alterations have been comprehensively charted, but the improvement of cancer patient management somewhat lags behind these basic breakthroughs. Recently, large-scale sequencing that focused on metastasis,...

Topics

Breast Neoplasms
Clonal Evolution
DNA Mutational Analysis
Disease Progression
Female
Gene Expression Regulation, Neoplastic
High-Throughput Nucleotide Sequencing
Humans
Molecular Targeted Therapy
Mutation
Neoplasm Metastasis
Prognosis

Source

Open in PubMed

Identifiers

PMID: 32245795
DOI: 10.1158/0008-5472.CAN-19-3260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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