Article

Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice

2024-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear whether naltrexone blocks a direct effect of ketamine at ORs, or whether normal functioning of the OR system is required to realize the full antidepressant effect...

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Literature Corpus work: 81c02b34-38c4-559d-ad62-3fbf38690934
DOI: 10.1101/2024.03.03.583196

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