Article

The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathways

2025-11-19

Abstract excerpt

<title>Abstract</title> <p> Background Chronic neuropathic pain is frequently accompanied by anxiety and depression, yet the cortical circuit mechanisms underlying this comorbidity remain unclear. The medial orbitofrontal cortex (mOFC) is a key cortical region involved in emotional regulation and valuation, and clinical imaging studies have reported altered mOFC activity in patients with chronic pain. However, i...

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Literature Corpus work: 19f00b8a-7ab8-5bc1-9573-6e035f67d469
DOI: 10.21203/rs.3.rs-8000273/v1

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