Article

(2R,6R)-Hydroxynorketamine restores postsynaptic localization of AMPAR in the prelimbic cortex to provide sustained pain relief

2022-11-17

Abstract excerpt

<title>Abstract</title> <p>Neuropathic pain is a difficult-to-treat pain condition that can affect patients for years. (2R,6R)-hydroxynorketamine (R-HNK) is a ketamine metabolite without dissociative effects and has been evaluated as an alternative to ketamine in chronic pain management. The mechanism of action remains elusive. Here we report that repeated systemic or contra-prelimbic cortex (PrL) infusion of R-H...

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Literature Corpus work: 0e260d8c-12ee-5c77-96d4-0799870810a2
DOI: 10.21203/rs.3.rs-2261014/v1

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(2R,6R)-Hydroxynorketamine restores postsynaptic localization of AMPAR in the prelimbic cortex to provide sustained pain reliefDOI 10.21203/rs.3.rs-2261014/v1Read

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