Article

( <i>R,S</i> )-ketamine’s rapid-acting antidepressant effects are modulated by NR2B-containing NMDA receptors on adult-born hippocampal neurons

2023-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Standard antidepressant treatments often take weeks to reach efficacy and are ineffective for many patients. ( R,S )-ketamine, an N -methyl-D-aspartate (NMDA) antagonist, has been shown to be a rapid-acting antidepressant and to decrease depressive symptoms within hours of administration. While previous studies have shown the importance of the NR2B subunit of the NMDA receptor (NMDAR) on inter...

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Literature Corpus work: 00c092c1-168c-57f4-98c8-b2764db59ab3
DOI: 10.1101/2023.11.28.569043

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