Article

An Isogenic Cell Line Panel for Sequence-based Screening of Targeted Anti-cancer Drugs

2021-08-08

Abstract excerpt

<h4>Summary</h4> We describe the creation and characterization of an isogenic cell line panel representing common cancer pathways, with multiple features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cells were generated using CRISPR-technologies. Surprisingly, we discovered most of these lines did not result in complete gene inactivation, despite integration of sgRNA...

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Literature Corpus work: 81bae9f2-c719-5ac6-9944-f1a81f950c77
DOI: 10.1101/2021.08.06.455336

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