Application of CRISPR/Cas9 screening to study cancer drivers and to identify novel cancer vulnerabilities

Abstract excerpt

The development of targeted therapies has had a significant impact on cancer survival rates. However, targeting cancers that are driven by loss of tumour suppressor genes remains a major challenge. One promising approach to treat these cancers is the exploitation of synthetic lethal interactions. Synthetic lethality describes an interaction between two genes, where loss of one gene alone does not affect viability...

Topics

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• Cell Line
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Gene Editing
• Genetic Therapy
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

d2fae186-2839-512c-9f28-9aa7f6bc045f

DOI

10.17863/cam.50566