Article

Challenges and opportunities for drug repurposing in cancers based on synthetic lethality induced by tumor suppressor gene mutations

2025-03-22

Abstract excerpt

Although two-thirds of cancers arise from loss-of-function mutations in tumor suppressor genes, there are few approved targeted therapies linked to these alterations. Synthetic lethality offers a promising strategy to treat such cancers by targeting vulnerabilities unique to cancer cells with these mutations. To identify clinically relevant synthetic lethal interactions, we analyzed genome-wide CRISPR/Cas9 knock-o...

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Literature Corpus work: 06a4fd40-d2d7-578c-92b9-50d47875ecc0
DOI: 10.1101/2025.03.20.644275

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