Article

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics

2023-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Combination chemotherapy is crucial for achieving durable cancer cures, however, developing safe and effective drug combinations has been a significant challenge. To improve this process, we conducted large-scale targeted CRISPR knockout screens in drug-treated cells, creating a genetic map of druggable genes that sensitize cells to commonly used chemotherapeutics. We prioritized neuroblastoma,...

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Literature Corpus work: b1a5239d-a5e3-51f1-a1e4-8d8838716c05
DOI: 10.1101/2023.04.12.536612

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