Article

<i>In silico</i> characterization of mechanisms positioning costimulatory and checkpoint complexes in immune synapses

2020-01-17

Abstract excerpt

Integrin and small immunoglobulin superfamily (sIGSF) adhesion complexes function physiologically in human immunological synapses (IS) wherein sIGSF complexes form a corolla of microdomains around an integrin ring and secretory core. The corolla recruits and retains the major costimulatory and checkpoint complexes that regulate the response to T cell receptor (TCR) engagement, making forces that govern corolla for...

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Identifiers and source

Literature Corpus work: 81b6218d-6498-54fc-b3a4-df6d38903c33
DOI: 10.1101/2020.01.16.908723

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