Article

A Comprehensive Mathematical Model of Avidity in Cytokine Signaling

2026-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Multivalent ligand–receptor interactions underlie most forms of cell-cell communication, yet a general quantitative framework for “avidity” has remained elusive for over a century. Here, we derive closed-form expressions for signaling potency (EC 50 ) in multivalent systems directly from first principles, extending exact analytical models of ternary complex equilibria to account for receptor co...

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Literature Corpus work: 3597b654-dc9c-5c96-a1f0-a81f3db27b15
DOI: 10.64898/2026.04.29.721617

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