License to Clump: Secretory IgA Structure–Function Relationships Across Scales

Abstract excerpt

Secretory antibodies are the only component of our adaptive immune system capable of attacking mucosal pathogens topologically outside of our bodies. All secretory antibody classes are ( a) relatively resistant to harsh proteolytic environments and ( b) polymeric. Recent elucidation of the structure of secretory IgA (SIgA) has begun to shed light on SIgA functions at the nanoscale. We can now begin to unravel the...

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